[2,3] Hence, the 5 fold higher dosage of agalsidase

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In their recent study Arends and colleagues demonstrate a significant 2.8 fold increased risk for the celine bag replica uk formation of neutralizing anti drug antibodies (ADA) in male patients with Fabry disease (FD) when treated with agalsidase beta (1.0 mg/kg every other week) compared to agalsidase alfa (0.2 mg/kg every other week).[1] Interestingly, Rombach and colleagues and later Smid and colleagues reported celine outlet singapore no significant differences in a humoral response, when using an identical dosage of 0.2 mg/kg for both drugs. [2,3] Hence, the 5 fold higher dosage of agalsidase beta and not the compound itself seems to be an important trigger for antibody formation. However, none of the studies determined the cross reactive immunological status, which is crucial for the risk of a humoral response.

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